const buf = Buffer.allocUnsafe(4);

buf.writeUInt16BE(0xdead, 0);
buf.writeUInt16BE(0xbeef, 2);

// Prints: <Buffer de ad be ef>
console.log(buf);

buf.writeUInt16LE(0xdead, 0);
buf.writeUInt16LE(0xbeef, 2);

// Prints: <Buffer ad de ef be>
console.log(buf);